Rodrigo Cristofoletti

Smart Trop-2 CAR-T with Synthetic Circuits for TNBC Precision

Vascularized fetal liver-hematopoietic niche-on-chip to decode erythroid dysregulation in Down syndrome

Quantitative Systems Pharmacology (QSP) Research Project

Development and verification of mechanism-based translational disease modeling platform for neurodegenerative disorders

Vibrio microcins. A hidden field of targeted anti-cholerae natural products

Liquid biopsy technology towards individualized immunosuppression therapy

Characterizing antibiotic efficacy via latest hollow fiber infection models and organs on a chip

Improving translatability of drug-drug interactions arising from CYP induction for drugs with low Km using carbamazepine as a CYP induction calibrator: assessing inter-organ relationship between enzyme expression and activity of gut and liver enzymes in m

Feasibility of predicting regional lung exposure from systemic pharmacokinetic data of generic OIDPs via population pharmacokinetic modeling and non-compartmental approaches

State of the Art Virtual Bioequivalence Platform Integrated with a Bayesian Framework to Assess Bioequivalence Based on Systemic and/or Local Concentrations

Physiologically-based Pharmacokinetic (PBPK) Modeling of Drug-drug interactions (DDI) for TEV-56268

Assessing the in vitro performance of solid dosage forms overencapsulated with the ID-Cap System for improved compliance

Model Integrated Evidence Approach for Intravesical Drug Delivery for Localized Bladder Disease

Characterizing efficacy and safety of hormonal contraceptives by combining pharmacometrics and RWE

Advancing In Vitro and (patho) Physiology-Based Pharmacokinetics Models to Understand and Predict Pulmonary Absorption and Tissue Retention of Inhaled Drugs

Development and verification of in vitro integrated mechanistic population-based PBPK model framework towards virtual bioequivalence assessment of locally acting drug products in the GI tract

Development of a biopharmaceutics roadmap for integrating in vitro data with gastrointestinal physiology in PBPK models

Development and validation of a best practices framework for PBPK analysis for biopharmaceutic applications in support of model-informed biowaivers of fed state BE studies for BCS class II drugs

Using Physiologically-Based Pharmacokinetic (PBPK) Simulation Approaches to Evaluate Drug-Drug-Interactions (DDIs)

Integrating Dissolution and Translational Modeling Strategies to Establish In Vitro-In Vivo Links

Assessing the impact of highly prevalent chronic comorbidities on antifungal treatment in elderly patients: disease-based modeling as a candle in the dark

Application of physiologically-based pharmacokinetic models to inform dosing recommendations for hormonal contraceptives co-administered with other medications